Rozbudowa centrum Badawczo-Rozwojowego Selvita S.A.
As a result of population aging and impact of environmental factors, there is an increase in mortality related to oncological diseases. Despite the progress of basic research and the development of new treatment strategies, many cancers remain incurable. One of the hallmarks of cancer cells is altered metabolism, which must meet increased energy and anabolic demands of cancer cells. Many of the first generation chemotherapeutics are antimetabolites – molecules that block key metabolic processes of cancer cells due to significant structural similarity to natural metabolites. Despite proven effectiveness in clinical practice, antimetabolites are characterized by a number of significant disadvantages that are due to the lack of specificity and presence of side effects. The research studies allowed identification of key points of metabolism, protein molecular targets and markers of sensitivity and selection of patients. Based on this knowledge, new active molecules will be designed and developed allowing a targeted therapeutic approach. These molecules in addition to greater efficiency, provided by a personalized therapy, will be characterized by safety of use due to the specificity of action. Molecular targets selected for the project should give a good chance of obtaining a first-in-class drug.
Lead compounds will be fully characterized in terms of pharmacodynamics and pharmacokinetics and initially toxicologically evaluated. A full package of toxicological and safety pharmacology in GLP standard will be performed for the clinical candidate. Subsequently CMC manufacturing in GMP standard together with performance of phase I clinical trial are the key parts of the current proposal.
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