Antiviral activity of interferon induced transmembrane proteins (IFITM) as a novel therapeutic strategy to control viral infections – evaluation in vitro and in vivo
Interferon induced transmembrane proteins – IFITM1, IFITM2 and IFITM3 are cellular proteins and effectors of anti-viral innate immune responses. They exhibit inhibitory activity towards numerous viral pathogens, including influenza, West Nile virus, dengue virus, SARS coronavirus, hepatitis C virus, HIV, Ebola, Marburg and Zika virus. Their recently discovered anti-viral properties led to assumptions that they could be used as a component of anti-viral therapies. In this project, we will explore IFITMs functions against tick-borne encephalitis virus (TBEV) and hepatitis C virus (HCV) infection. We will test a novel anti-viral gene therapy approach in in vivo experiments using HCV as a model. We will conduct in vitro experiments to investigate the mechanisms of IFITM activity in the aspect of blocking viral spread from infected cell to adjacent cells. Finally, we aim to investigate TBEV as a new possible target for IFITMs actions and a candidate for any future IFITM-based therapies.
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